Activity-dependent K+ accumulation in the developing rat optic nerve

Barry W. Connors; Bruce R. Ransom; David M. Kunis; Michael J. Gutnick

doi:10.1126/science.7079771

Activity-dependent K⁺ accumulation in the developing rat optic nerve

Barry W. Connors^*
, Bruce R. Ransom
, David M. Kunis
, Michael J. Gutnick

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

145 Scopus citations

Abstract

Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K⁺] _o) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K₊]_o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K ⁺]_o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K⁺]_o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K⁺ release.

Original language	English
Pages (from-to)	1341-1343
Number of pages	3
Journal	Science
Volume	216
Issue number	4552
DOIs	https://doi.org/10.1126/science.7079771
State	Published - 1982
Externally published	Yes

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title = "Activity-dependent K+ accumulation in the developing rat optic nerve",

abstract = "Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+] o) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+]o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K +]o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K+]o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release.",

author = "Connors, \{Barry W.\} and Ransom, \{Bruce R.\} and Kunis, \{David M.\} and Gutnick, \{Michael J.\}",

year = "1982",

doi = "10.1126/science.7079771",

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AU - Connors, Barry W.

AU - Ransom, Bruce R.

AU - Kunis, David M.

AU - Gutnick, Michael J.

PY - 1982

Y1 - 1982

N2 - Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+] o) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+]o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K +]o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K+]o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release.

AB - Potassium-sensitive microelectrodes were used to study activity-dependent changes of extracellular potassium ion concentration ([K+] o) in rat optic nerves of different postnatal ages (1 day to adulthood). The maximum level to which [K+]o rose with optimal frequencies of stimulation depended on age: mean maximum evoked [K +]o was 17.2 mM in 1- to 3-day-old optic nerves and 9.8 mM in adult nerves. The ceiling [K+]o seen in immature optic nerves, which is uniquely large for a mammalian central nervous system structure, may result from a relatively enhanced rate of evoked K+ release.

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IS - 4552

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Activity-dependent K⁺ accumulation in the developing rat optic nerve

Abstract

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