Activity of compound G2 isolated from alfalfa roots against medically important yeasts

I. Polacheck, U. Zehavi, M. Naim, M. Levy, R. Evron

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26 Scopus citations

Abstract

An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 μg/ml. Compound G2 was fungicidal at a relatively concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 μg/ml. The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent n the treatment of mycotic infections.

Original languageEnglish
Pages (from-to)290-294
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume30
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

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