TY - JOUR
T1 - Acute oral cannabidiolic acid methyl ester reduces depression-like behavior in two genetic animal models of depression
AU - Hen-Shoval, D.
AU - Amar, S.
AU - Shbiro, L.
AU - Smoum, R.
AU - Haj, Christeene G.
AU - Mechoulam, R.
AU - Zalsman, G.
AU - Weller, A.
AU - Shoval, G.
N1 - Publisher Copyright:
© 2018
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
AB - Background and purpose: Cannabidiolic acid methyl ester (HU-580) was recently shown to reduce stress-induced anxiety-like behavior in rats. The aim of this study was to examine the antidepressant effect of HU-580 in two different rat models of depression. Experimental approach: Using the forced swim test (FST), we evaluated the effect of HU-580 in 43 Wistar–Kyoto (WKY) and 23 Flinders Sensitive Line (FSL) adult male rats. Key results: 1 mg/kg HU-580 reduced immobility and increased swimming in WKY rats, compared to vehicle-treated controls (p < 0.05). This dose exerted similar effects in FSL rats (p < 0.05). Conclusion and implications: This is the first report of antidepressant efficacy of HU-580. These findings expand the very limited existent results, suggesting that HU-580 is a potent anxiolytic agent. Taken together with its chemical stability, HU-580 emerges as a candidate for a future antidepressant medication.
KW - Cannabidiolic acid methyl ester
KW - Flinders Sensitive Line (FSL)
KW - Forced swim test (FST)
KW - Genetic animal models of depression
KW - Major depression disorder (MDD)
KW - Wistar–Kyoto (WKY)
UR - https://www.scopus.com/pages/publications/85047846392
U2 - 10.1016/j.bbr.2018.05.027
DO - 10.1016/j.bbr.2018.05.027
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C2 - 29860002
AN - SCOPUS:85047846392
SN - 0166-4328
VL - 351
SP - 1
EP - 3
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -