TY - JOUR
T1 - Adaptive phenomenon of ischemic postconditioning of the heart. Perspectives of clinical use
AU - Maslov, L. N.
AU - Mrochek, A. G.
AU - Khaliulin, I.
AU - Hanus, L.
AU - Pei, J. M.
AU - Zhang, Y.
PY - 2013
Y1 - 2013
N2 - Analysis of experimental data indicates that aging, metabolic syndrome may be serious obstacle against realization of cardioprotective effect of postconditioning. The moderate hypercholesterolemia, postinfarction cardiosclerosis and cardiac hypertrophy do not abolish protective effect of postconditioning in experimental animals. The issue whether diabetes mellitus and arterial hypertension affect an efficacy of postconditioning is a subject of discussion. Clinical investigations testify on cardioprotective impact of postconditioning in patients with acute myocardial infarction and cardiosurgery patients. At the same time, it is remained unclear when after coronary artery occlusion postconditioning exhibits cardioprotective effect. It is remained unknown how do affect aging, diabetes mellitus, metabolic syndrome, arterial hypertension, myocardial hypertrophy, cardiac postinfarction remodeling and efficacy postconditioning in clinical praxis. It is required a further clinical investigations turning the development pharmacological approaches to prophylaxis of reperfusion injury of the heart.
AB - Analysis of experimental data indicates that aging, metabolic syndrome may be serious obstacle against realization of cardioprotective effect of postconditioning. The moderate hypercholesterolemia, postinfarction cardiosclerosis and cardiac hypertrophy do not abolish protective effect of postconditioning in experimental animals. The issue whether diabetes mellitus and arterial hypertension affect an efficacy of postconditioning is a subject of discussion. Clinical investigations testify on cardioprotective impact of postconditioning in patients with acute myocardial infarction and cardiosurgery patients. At the same time, it is remained unclear when after coronary artery occlusion postconditioning exhibits cardioprotective effect. It is remained unknown how do affect aging, diabetes mellitus, metabolic syndrome, arterial hypertension, myocardial hypertrophy, cardiac postinfarction remodeling and efficacy postconditioning in clinical praxis. It is required a further clinical investigations turning the development pharmacological approaches to prophylaxis of reperfusion injury of the heart.
KW - Acute myocardial infarction
KW - Cardiosurgery intervention
KW - Heart
KW - Ischemia
KW - Reperfusion
UR - http://www.scopus.com/inward/record.url?scp=84890401303&partnerID=8YFLogxK
U2 - 10.15690/vramn.v68i1.532
DO - 10.15690/vramn.v68i1.532
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C2 - 23805634
AN - SCOPUS:84890401303
SN - 0869-6047
SP - 10
EP - 20
JO - Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
JF - Vestnik Rossiiskoi Akademii Meditsinskikh Nauk
IS - 1
ER -