Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate

R. Brandes; R. Hertz; R. Arad; S. Naishtat; S. Weil; J. Bar-Tana

doi:10.1016/0024-3205(87)90312-2

Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate

R. Brandes^*, R. Hertz, R. Arad, S. Naishtat, S. Weil, J. Bar-Tana

^*Corresponding author for this work

Braun School of Public Health and Community Medicine

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Abstract

Transient exposure of cultured 3T3-Ll preadipocytes to hypolipidemic fibrate drugs results in extensive adipocyte conversion. Adipocyte conversion in culture was characterized by an increase in neutral lipids content and in adipocyte marker enzymes like hormone-sensitive lipase and glycerol-3-phosphate dehydrogenase. Adipocyte conversion in culture was also accompanied by induction of cyanide-insensitive peroxisomal palmitoyl-CoA oxidation. The conversion pattern exerted by fibrate drugs in 3T3-Ll cells was similar to that reported previously for primary cultured epididymal preadipocytes (R. Brandes, R. Arad and J. Bar-Tana, Biochim. Biophys. Acta, 877, 314-321 (1986)), and seems to refute clonal selection in the conversion sequel initiated by fibrate drugs in primary cultured preadipocytes.

Original language	English
Pages (from-to)	935-941
Number of pages	7
Journal	Life Sciences
Volume	40
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(87)90312-2
State	Published - 9 Mar 1987

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title = "Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate",

abstract = "Transient exposure of cultured 3T3-Ll preadipocytes to hypolipidemic fibrate drugs results in extensive adipocyte conversion. Adipocyte conversion in culture was characterized by an increase in neutral lipids content and in adipocyte marker enzymes like hormone-sensitive lipase and glycerol-3-phosphate dehydrogenase. Adipocyte conversion in culture was also accompanied by induction of cyanide-insensitive peroxisomal palmitoyl-CoA oxidation. The conversion pattern exerted by fibrate drugs in 3T3-Ll cells was similar to that reported previously for primary cultured epididymal preadipocytes (R. Brandes, R. Arad and J. Bar-Tana, Biochim. Biophys. Acta, 877, 314-321 (1986)), and seems to refute clonal selection in the conversion sequel initiated by fibrate drugs in primary cultured preadipocytes.",

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AU - Brandes, R.

AU - Hertz, R.

AU - Arad, R.

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AU - Weil, S.

AU - Bar-Tana, J.

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N2 - Transient exposure of cultured 3T3-Ll preadipocytes to hypolipidemic fibrate drugs results in extensive adipocyte conversion. Adipocyte conversion in culture was characterized by an increase in neutral lipids content and in adipocyte marker enzymes like hormone-sensitive lipase and glycerol-3-phosphate dehydrogenase. Adipocyte conversion in culture was also accompanied by induction of cyanide-insensitive peroxisomal palmitoyl-CoA oxidation. The conversion pattern exerted by fibrate drugs in 3T3-Ll cells was similar to that reported previously for primary cultured epididymal preadipocytes (R. Brandes, R. Arad and J. Bar-Tana, Biochim. Biophys. Acta, 877, 314-321 (1986)), and seems to refute clonal selection in the conversion sequel initiated by fibrate drugs in primary cultured preadipocytes.

AB - Transient exposure of cultured 3T3-Ll preadipocytes to hypolipidemic fibrate drugs results in extensive adipocyte conversion. Adipocyte conversion in culture was characterized by an increase in neutral lipids content and in adipocyte marker enzymes like hormone-sensitive lipase and glycerol-3-phosphate dehydrogenase. Adipocyte conversion in culture was also accompanied by induction of cyanide-insensitive peroxisomal palmitoyl-CoA oxidation. The conversion pattern exerted by fibrate drugs in 3T3-Ll cells was similar to that reported previously for primary cultured epididymal preadipocytes (R. Brandes, R. Arad and J. Bar-Tana, Biochim. Biophys. Acta, 877, 314-321 (1986)), and seems to refute clonal selection in the conversion sequel initiated by fibrate drugs in primary cultured preadipocytes.

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Adipocyte conversion of cultured 3T3-Ll preadipocytes by bezafibrate

Abstract

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