Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals

Michael F. Johnston; Edward A. Kravitz; Halina Meiri; Rami Rahamimoff

doi:10.1126/science.6133353

Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals

Michael F. Johnston^*
, Edward A. Kravitz
, Halina Meiri
, Rami Rahamimoff

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.

Original language	English
Pages (from-to)	1071-1072
Number of pages	2
Journal	Science
Volume	220
Issue number	4601
DOIs	https://doi.org/10.1126/science.6133353
State	Published - 1983

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title = "Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals",

abstract = "Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.",

author = "Johnston, \{Michael F.\} and Kravitz, \{Edward A.\} and Halina Meiri and Rami Rahamimoff",

year = "1983",

doi = "10.1126/science.6133353",

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AU - Johnston, Michael F.

AU - Kravitz, Edward A.

AU - Meiri, Halina

AU - Rahamimoff, Rami

PY - 1983

Y1 - 1983

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AB - Exposure of frog neuromuscular preparations to adrenocorticotropic hormone for several minutes increased both nerve-evoked and spontaneous transmitter release for several hours. No changes in postsynaptic sensitivity to transmitter were detected. The long-lasting potentiation shows little sensitivity to changes in extracellular calcium concentration and seems to be entirely presynaptic in origin.

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EP - 1072

JO - Science

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IS - 4601

ER -

Adrenocorticotropic hormone causes long-lasting potentiation of transmitter release from frog motor nerve terminals

Abstract

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