Abstract
Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association
Original language | English |
---|---|
Pages (from-to) | 1419-1433 |
Number of pages | 15 |
Journal | International Journal of Epidemiology |
Volume | 41 |
Issue number | 5 |
DOIs | |
State | Published - 1 Oct 2012 |
Externally published | Yes |
Keywords
- Cancer
- Cardiovascular disease
- Cause-specific mortality
- Epidemiological study
- Height
- Meta-analysis
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In: International Journal of Epidemiology, Vol. 41, No. 5, 01.10.2012, p. 1419-1433.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Adult height and the risk of cause-specific death and vascular morbidity in 1 million people
T2 - Individual participant meta-analysis
AU - Wormser, David
AU - Di Angelantonio, Emanuele
AU - Kaptoge, Stephen
AU - Wood, Angela M.
AU - Gao, Pei
AU - Sun, Qi
AU - Walldius, Göran
AU - Selmer, Randi
AU - Monique Verschuren, W. M.
AU - Bueno-de-Mesquita, H. Bas
AU - Engström, Gunnar
AU - Ridker, Paul M.
AU - Njølstad, Inger
AU - Iso, Hiroyasu
AU - Holme, Ingar
AU - Giampaoli, Simona
AU - Tunstall-Pedoe, Hugh
AU - Gaziano, J. Michael
AU - Brunner, Eric
AU - Kee, Frank
AU - Tosetto, Alberto
AU - Meisinger, Christa
AU - Brenner, Hermann
AU - Ducimetiere, Pierre
AU - Whincup, Peter H.
AU - Tipping, Robert W.
AU - Ford, Ian
AU - Cremer, Peter
AU - Hofman, Albert
AU - Wilhelmsen, Lars
AU - Clarke, Robert
AU - de Boer, Ian H.
AU - Jukema, J. Wouter
AU - Ibañez, Alejandro Marín
AU - Lawlor, Debbie A.
AU - D'Agostino, Ralph B.
AU - Rodriguez, Beatriz
AU - Casiglia, Edoardo
AU - Stehouwer, Coen D.A.
AU - Simons, Leon A.
AU - Nietert, Paul J.
AU - Barrett-Connor, Elizabeth
AU - Panagiotakos, Demosthenes B.
AU - Björkelund, Cecilia
AU - Strandberg, Timo E.
AU - Wassertheil-Smoller, Sylvia
AU - Blazer, Dan G.
AU - Meade, Tom W.
AU - Welin, Lennart
AU - Svärdsudd, Kurt
AU - Woodward, Mark
AU - Nissinen, Aulikki
AU - Kromhout, Daan
AU - Jørgensen, Torben
AU - Tilvis, Reijo S.
AU - Guralnik, Jack M.
AU - Rosengren, Annika
AU - Taylor, James O.
AU - Kiechl, Stefan
AU - Dagenais, Gilles R.
AU - Fowkes, F. Gerry R.
AU - Wallace, Robert B.
AU - Khaw, Kay Tee
AU - Shaffer, Jonathan A.
AU - Visser, Marjolein
AU - Kauhanen, Jussi
AU - Salonen, Jukka T.
AU - Gallacher, John
AU - Ben-Shlomo, Yoav
AU - Kitamura, Akihiko
AU - Sundström, Johan
AU - Wennberg, Patrik
AU - Kiyohara, Yutaka
AU - Daimon, Makoto
AU - de la Cámara, Agustin Gómez
AU - Cooper, Jackie A.
AU - Onat, Altan
AU - Devereux, Richard
AU - Mukamal, Kenneth J.
AU - Dankner, Rachel
AU - Knuiman, Matthew W.
AU - Crespo, Carlos J.
AU - Gansevoort, Ron T.
AU - Goldbourt, Uri
AU - Nordestgaard, Børge G.
AU - Shaw, Jonathan E.
AU - Mussolino, Michael
AU - Nakagawa, Hidaeki
AU - Fletcher, Astrid
AU - Kuller, Lewis H.
AU - Gillum, Richard F.
AU - Gudnason, Vilmundur
AU - Assmann, Gerd
AU - Wald, Nicholas
AU - Jousilahti, Pekka R.
AU - Greenland, Philip
AU - Trevisan, Maurizio
AU - Ulmer, Hanno
AU - Butterworth, Adam S.
AU - Folsom, Aaron R.
AU - Davey-Smith, George
AU - Hu, Frank B.
AU - Danesh, John
AU - Simpson, Lara M.
AU - Jungner, Ingmar
AU - Demerath, Ellen W.
AU - Franceschini, Nora
AU - Lutsey, Pamela L.
AU - Pitsavos, Christos
AU - Chrysohoou, Christina
AU - Stefanadis, Christodoulos
AU - Atkins, Robert
AU - Zimmet, Paul Z.
AU - Barr, Elizabeth L.M.
AU - Wannamethee, S. Goya
AU - Morris, Richard W.
AU - Willeit, Johann
AU - Weger, Siegfried
AU - Oberhollenzer, Friedrich
AU - Ebrahim, Shah
AU - Yarnell, John W.G.
AU - Tikhonoff, Valérie
AU - Shay, Christina M.
AU - Garside, Daniel B.
AU - Sutherland, Susan E.
AU - Bachman, David L.
AU - Keil, Julian E.
AU - Kizer, Jorge R.
AU - Psaty, Bruce M.
AU - Tybjærg-Hansen, Anne
AU - Jensen, Gorm B.
AU - Schnohr, Peter
AU - Palmieri, Luigi
AU - Panico, Salvatore
AU - Pilotto, Lorenza
AU - Vanuzzo, Diego
AU - Simons, Judith
AU - McCallum, John
AU - Friedlander, Yechiel
AU - Phillips, Caroline L.
AU - Kohout, Frank J.
AU - Cornoni-Huntley, Joan C.
AU - Wareham, Nicholas J.
AU - Schöttker, Ben
AU - Müller, Heiko
AU - Rothenbacher, Dietrich
AU - Jansson, Jan Håkan
AU - Donfrancesco, Chiara
AU - Vartiainen, Erkki
AU - Harald, Kennet
AU - Salomaa, Veikko
AU - Vasan, Ramachandran S.
AU - Fox, Caroline S.
AU - Pencina, Michael J.
AU - Oizumi, Toshihide
AU - Kayama, Takamasa
AU - Kato, Takeo
AU - Bladbjerg, Else Marie
AU - Møller, Lars
AU - Jespersen, Jørgen
AU - Chetrit, Angela
AU - Lubin, Flora
AU - Eriksson, Henry
AU - Lappas, Georgios
AU - Bengtsson, Calle
AU - Lissner, Lauren
AU - Nagel, Dorothea
AU - Miettinen, Tatu A.
AU - Arima, Hisatomi
AU - Doi, Yasufumi
AU - Ninomiya, Toshiharu
AU - Dekker, Jacqueline M.
AU - Nijpels, Giel
AU - Rimm, Eric B.
AU - Willett, Walter C.
AU - Yamagishi, Kazumasa
AU - Noda, Hiroyuki
AU - Kurl, Sudhir
AU - Tuomainen, Tomi Pekka
AU - Poppelaars, Jan L.
AU - Deeg, Dorly J.H.
AU - De Stavola, Bianca Lucia
AU - Hedblad, Bo
AU - Nilsson, Peter
AU - Blokstra, Anneke
AU - Shea, Steven J.
AU - Thorand, Barbara
AU - Koenig, Wolfgang
AU - Döring, Angela
AU - Nitsch, Dorothea
AU - Grandits, Greg
AU - Tverdal, Aage
AU - Nystad, Wenche
AU - Manson, Joann E.
AU - Hankinson, Susan E.
AU - Bauer, Kenneth A.
AU - Davidson, Karina W.
AU - Kirkland, Susan
AU - Shimbo, Daichi
AU - Sato, Shinichi
AU - Miura, Katsuyuki
AU - Sakurai, Masaru
AU - Jouven, Xavier
AU - Bakker, Stephan J.L.
AU - van der Harst, Pim
AU - Hillege, Hans L.
AU - Garcia-Palmieri, Mario R.
AU - Amouyel, Philippe
AU - Arveiler, Dominique
AU - Ferrières, Jean
AU - Schulte, Helmut
AU - de Craen, Anton J.M.
AU - Sattar, Naveed
AU - Stott, David J.
AU - Cantin, Bernard
AU - Lamarche, Benoît
AU - Després, Jean Pierre
AU - Bergstrom, Jaclyn
AU - Bettencourt, Richele R.
AU - Buisson, Catherine
AU - Aspelund, Thor
AU - Sigurdsson, Gunnar
AU - Thorsson, Bolli
AU - Ikram, M. Arfan
AU - Tiemeier, Henning
AU - Witteman, Jacqueline C.M.
AU - Tavendale, Roger
AU - Lowe, Gordon D.O.
AU - Yeh, Jeun Liang
AU - Ali, Tauqeer
AU - Calhoun, Darren
AU - Can, Günay
AU - Nakamura, Koshi
AU - Morikawa, Yuko
AU - Mathiesen, Ellisiv B.
AU - Løchen, Maja Lisa
AU - Wilsgaard, Tom
AU - Ingelsson, Erik
AU - Michaëlsson, Karl
AU - Cederholm, Tommy
AU - Buring, Julie
AU - Diem, Günter
AU - Concin, Hans
AU - Rodeghiero, Francesco
AU - Marmot, Michael
AU - Kivimaki, Martin Shipley Mika
AU - Robertson, Michele
AU - Feskens, Edith
AU - Geleijnse, Johanna M.
AU - Kromhout, Daan
AU - Walker, Matthew
AU - Watson, Sarah
AU - Alexander, Myriam
AU - Franco, Oscar H.
AU - Gobin, Reeta
AU - Haycock, Philip
AU - Kaptoge, Stephen
AU - Seshasai, Sreenivasa R.Kondapally
AU - Lewington, Sarah
AU - Pennells, Lisa
AU - Rapsomaniki, Eleni
AU - Sarwar, Nadeem
AU - Thompson, Alexander
AU - Thompson, Simon G.
AU - White, Ian R.
AU - Zhao, Xiaohui
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association
AB - Background: The extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain. Methods: We calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies. Results: For people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators. Conclusion: Adult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases. Published by Oxford University Press on behalf of the International Epidemiological Association
KW - Cancer
KW - Cardiovascular disease
KW - Cause-specific mortality
KW - Epidemiological study
KW - Height
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84867619105&partnerID=8YFLogxK
U2 - 10.1093/ije/dys086
DO - 10.1093/ije/dys086
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 22825588
AN - SCOPUS:84867619105
SN - 0300-5771
VL - 41
SP - 1419
EP - 1433
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 5
ER -