Adult hepatocytes are generated by self-duplication rather than stem cell differentiation

Kilangsungla Yanger, David Knigin, Yiwei Zong, Lara Maggs, Guoqiang Gu, Haruhiko Akiyama, Eli Pikarsky, Ben Z. Stanger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

344 Scopus citations


The liver is thought to utilize facultative stem cells, also known as "oval cells" or "atypical ductal cells" (ADCs), for regeneration following various types of injury. However, this notion has been based largely on in vitro studies and transplantation models; where lineage tracing has been used, results have been conflicting and effect sizes have been small. Here, we used genetic and nucleoside analog-based tools to mark and track the origin and contribution of various cell populations to liver regeneration in vivo following several ADC-inducing insults. We report that, contrary to prevailing stem-cell-based models of regeneration, virtually all new hepatocytes come from preexisting hepatocytes.

Original languageAmerican English
Pages (from-to)340-349
Number of pages10
JournalCell Stem Cell
Issue number3
StatePublished - 2014
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc.


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