Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients

Lilach Soreq; Zvi Israel; Hagai Bergman; Hermona Soreq

doi:10.1016/j.jneuroim.2008.06.019

Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients

Lilach Soreq, Zvi Israel, Hagai Bergman, Hermona Soreq^*

^*Corresponding author for this work

Edmond & Lily Safra Center for Brain Sciences

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Laboratory tests for Parkinson's disease (PD) were recently extended to microarray analyses of nucleated blood cells. Here, we report the use of statistical and gene ontology tools to re-examine these microarray data. Distribution plots and PCA mapping enabled removal of several outliers out of the 105 analyzed PD and control samples, which improved the discriminative power for PD blood cells compared to healthy and neurological disease controls. Combined with gene ontology tests, our findings point at neuro-immune signaling-related transcripts as distinctly expressed early in PD progress and call for exploiting microarray tests also for follow-up of PD treatment efficacy.

Original language	English
Pages (from-to)	227-236
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	201-202
Issue number	C
DOIs	https://doi.org/10.1016/j.jneuroim.2008.06.019
State	Published - 15 Sep 2008

Bibliographical note

Funding Information:
We acknowledge the support by the ROSETREES Foundation and the Israeli Ministry of Science and Technology (to H.S.).

Keywords

ANOVA
Affymetrix 3′ microarrays
Blood
Gene ontology
Parkinson's disease

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10.1016/j.jneuroim.2008.06.019

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abstract = "Laboratory tests for Parkinson's disease (PD) were recently extended to microarray analyses of nucleated blood cells. Here, we report the use of statistical and gene ontology tools to re-examine these microarray data. Distribution plots and PCA mapping enabled removal of several outliers out of the 105 analyzed PD and control samples, which improved the discriminative power for PD blood cells compared to healthy and neurological disease controls. Combined with gene ontology tests, our findings point at neuro-immune signaling-related transcripts as distinctly expressed early in PD progress and call for exploiting microarray tests also for follow-up of PD treatment efficacy.",

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Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients

Abstract

Bibliographical note

Keywords

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