Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients

Lilach Soreq, Zvi Israel, Hagai Bergman, Hermona Soreq*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Laboratory tests for Parkinson's disease (PD) were recently extended to microarray analyses of nucleated blood cells. Here, we report the use of statistical and gene ontology tools to re-examine these microarray data. Distribution plots and PCA mapping enabled removal of several outliers out of the 105 analyzed PD and control samples, which improved the discriminative power for PD blood cells compared to healthy and neurological disease controls. Combined with gene ontology tests, our findings point at neuro-immune signaling-related transcripts as distinctly expressed early in PD progress and call for exploiting microarray tests also for follow-up of PD treatment efficacy.

Original languageAmerican English
Pages (from-to)227-236
Number of pages10
JournalJournal of Neuroimmunology
Volume201-202
Issue numberC
DOIs
StatePublished - 15 Sep 2008

Bibliographical note

Funding Information:
We acknowledge the support by the ROSETREES Foundation and the Israeli Ministry of Science and Technology (to H.S.).

Keywords

  • ANOVA
  • Affymetrix 3′ microarrays
  • Blood
  • Gene ontology
  • Parkinson's disease

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