Advances in Synthesis and Measurement of Charge Transport in DNA-Based Derivatives

Roman Zhuravel, Avigail Stern, Natalie Fardian-Melamed, Gennady Eidelshtein, Liat Katrivas, Dvir Rotem, Alexander B. Kotlyar*, Danny Porath

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Charge transport through molecular structures is interesting both scientifically and technologically. To date, DNA is the only type of polymer that transports significant currents over distances of more than a few nanometers in individual molecules. For molecular electronics, DNA derivatives are by far more promising than native DNA due to their improved charge-transport properties. Here, the synthesis of several unique DNA derivatives along with electrical characterization and theoretical models is surveyed. The derivatives include double stranded poly(G)–poly(C) DNA molecules, four stranded G4-DNA, metal–DNA hybrid molecular wires, and other DNA molecules that are modified either at the bases or at the backbone. The electrical characteristics of these nanostructures, studied experimentally by electrostatic force microscopy, conductive atomic force microscopy, and scanning tunneling microscopy and spectroscopy, are reviewed.

Original languageAmerican English
Article number1706984
JournalAdvanced Materials
Issue number41
StatePublished - 11 Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • DNA derivatives
  • DNA-based nanoelectronics
  • charge transport
  • molecular electronics
  • nanowires


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