Charge transport through molecular structures is interesting both scientifically and technologically. To date, DNA is the only type of polymer that transports significant currents over distances of more than a few nanometers in individual molecules. For molecular electronics, DNA derivatives are by far more promising than native DNA due to their improved charge-transport properties. Here, the synthesis of several unique DNA derivatives along with electrical characterization and theoretical models is surveyed. The derivatives include double stranded poly(G)–poly(C) DNA molecules, four stranded G4-DNA, metal–DNA hybrid molecular wires, and other DNA molecules that are modified either at the bases or at the backbone. The electrical characteristics of these nanostructures, studied experimentally by electrostatic force microscopy, conductive atomic force microscopy, and scanning tunneling microscopy and spectroscopy, are reviewed.
Bibliographical noteFunding Information:
R.Z., A.S., and N.F-.M. contributed equally to this work. The research was supported by the Israel Science Foundation (ISF grants 1589/14 and 2556/17) and by the Minerva Centre for bio-hybrid complex systems. D.P. thanks the Etta and Paul Schankerman Chair of Molecular Biomedicine.
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- DNA derivatives
- DNA-based nanoelectronics
- charge transport
- molecular electronics