Advances in the application of neuropeptides in insect control

Miriam Altstein; Orna Ben-Aziz; Irit Schefler; Irina Zeltser; Chaim Gilon

doi:10.1016/S0261-2194(00)00071-5

Advances in the application of neuropeptides in insect control

Miriam Altstein^*, Orna Ben-Aziz, Irit Schefler, Irina Zeltser, Chaim Gilon

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The development of a new approach for the generation of a novel type of putative insect control agents based on backbone cyclic peptidomimetic antagonists of insect-neuropeptides is reported. The approach, termed the backbone cyclic neuropeptide based on antagonist (BBC-NBA) was applied to the insect pyrokinin/pheromone biosynthesis activating neuropeptide (PBAN) family as a model, and led to the discovery of a potent linear lead antagonist and several highly potent, metabolically stable BBC peptidomimetic antagonists, devoid of agonistic activity, which inhibited in vivo PBAN-mediated activities in moths. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	547-555
Number of pages	9
Journal	Crop Protection
Volume	19
Issue number	8-10
DOIs	https://doi.org/10.1016/S0261-2194(00)00071-5
State	Published - 2000

Keywords

Insect neuropeptides
Neuropeptide antagonists
PBAN

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10.1016/S0261-2194(00)00071-5

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AU - Gilon, Chaim

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AB - The development of a new approach for the generation of a novel type of putative insect control agents based on backbone cyclic peptidomimetic antagonists of insect-neuropeptides is reported. The approach, termed the backbone cyclic neuropeptide based on antagonist (BBC-NBA) was applied to the insect pyrokinin/pheromone biosynthesis activating neuropeptide (PBAN) family as a model, and led to the discovery of a potent linear lead antagonist and several highly potent, metabolically stable BBC peptidomimetic antagonists, devoid of agonistic activity, which inhibited in vivo PBAN-mediated activities in moths. (C) 2000 Elsevier Science Ltd.

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Advances in the application of neuropeptides in insect control

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Keywords

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