Age-related changes in the concentration of transcobalamin II (TC II) in mouse peritoneal cells

M. Schlesinger, H. Zlotnick, R. Rabinowitz, B. Rachmilewitz, M. Rachmilewitz

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3 Scopus citations

Abstract

Previous studies have shown that mouse peritoneal macrophages synthesize transcobalamin II (TC II), the protein involved in the transport of vitamin B 12. In the present study, it was found that the concentration of TC II in peritoneal cells was age-dependent. The concentration of TC II was much higher in the macrophages of one-to-three-month-old mice than in those of older mice. The high concentration of TC II was restricted to the adherent population of peritoneal cells. Stimulation with thioglycollate elicited a similar increase in the concentration of TC II in peritoneal cells of young and old mice. In agreement with previous observations, the results obtained in the present study support the contention that a high intracellular concentration of TC II constitutes a biochemical marker for immature cells of the mononuclear macrophage system.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalRES Journal of the Reticuloendothelial Society
Volume30
Issue number3
StatePublished - 1981

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