Age-related myelin degradation burdens the clearance function of microglia during aging

Shima Safaiyan; Nirmal Kannaiyan; Nicolas Snaidero; Simone Brioschi; Knut Biber; Simon Yona; Aimee L. Edinger; Steffen Jung; Moritz J. Rossner; Mikael Simons

doi:10.1038/nn.4325

Age-related myelin degradation burdens the clearance function of microglia during aging

Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L. Edinger, Steffen Jung, Moritz J. Rossner, Mikael Simons^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

368 Scopus citations

Abstract

Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.

Original language	English
Pages (from-to)	995-998
Number of pages	4
Journal	Nature Neuroscience
Volume	19
Issue number	8
DOIs	https://doi.org/10.1038/nn.4325
State	Published - 1 Aug 2016
Externally published	Yes

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© 2016 Nature America, Inc.

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abstract = "Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.",

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AU - Brioschi, Simone

AU - Biber, Knut

AU - Yona, Simon

AU - Edinger, Aimee L.

AU - Jung, Steffen

AU - Rossner, Moritz J.

AU - Simons, Mikael

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Age-related myelin degradation burdens the clearance function of microglia during aging

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