Ageing and the mismatch repair system

Arie Ben Yehuda*, Amiela Globerson, Svetlana Krichevsky, Hanoch Bar On, Miriam Kidron, Yechiel Friedlander, Gideon Friedman, Dina Ben Yehuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Age-related accumulation of mutations has been extensively documented, and it has been proposed as one of the prominent causes of malignancies in old age. The present review is focused on the particular case of DNA mismatch repair system (MMR), that has drawn increased attention for its possible relevance to malignancy. We also report on our own observations on an age-associated genomic instability that develops with age in the MMR system. Our study was performed on DNA samples that were prepared from peripheral blood cells, obtained at a 10-year interval from young and old human subjects. The two DNA samples from each individual were examined comparatively. The older individuals showed a significantly higher rate of microsatellite instability (MSI) in several loci examined, whereas no difference was found between the paired samples of any of the young subjects. We suggest that this increase in MSI with age may indicate an overall genomic instability in the elderly.

Original languageAmerican English
Pages (from-to)173-179
Number of pages7
JournalMechanisms of Ageing and Development
Issue number1-3
StatePublished - 20 Jan 2001
Externally publishedYes

Bibliographical note

Funding Information:
Original experiments were supported by grants from the Israel Cancer Association (Dina Ben Yehuda) and the Rich Foundation (Dina Ben Yehuda). Amiela Globerson is the incumbent of the Harriet and Harold Brady Chair for Cancer Research.


  • Aging
  • Microsatellite instability (MSI)
  • Mismatch repair (MMR)


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