TY - JOUR
T1 - Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli.
AU - Ben-Ami, G.
AU - Ozeri, V.
AU - Hanski, E.
AU - Hofmann, F.
AU - Aktories, K.
AU - Hahn, K. M.
AU - Bokoch, G. M.
AU - Rosenshine, I.
PY - 1998/4
Y1 - 1998/4
N2 - Enteropathogenic Escherichia coli (EPEC) induces formation of actin pedestals in infected host cells. Agents that inhibit the activity of Rho, Rac, and Cdc42, including Clostridium difficile toxin B (ToxB), compactin, and dominant negative Rho, Rac, and Cdc42, did not inhibit formation of actin pedestals. In contrast, treatment of HeLa cells with ToxB inhibited EPEC invasion. Thus, Rho, Rac, and Cdc42 are not required for assembly of actin pedestals; however, they may be involved in EPEC uptake by HeLa cells.
AB - Enteropathogenic Escherichia coli (EPEC) induces formation of actin pedestals in infected host cells. Agents that inhibit the activity of Rho, Rac, and Cdc42, including Clostridium difficile toxin B (ToxB), compactin, and dominant negative Rho, Rac, and Cdc42, did not inhibit formation of actin pedestals. In contrast, treatment of HeLa cells with ToxB inhibited EPEC invasion. Thus, Rho, Rac, and Cdc42 are not required for assembly of actin pedestals; however, they may be involved in EPEC uptake by HeLa cells.
UR - http://www.scopus.com/inward/record.url?scp=0032036390&partnerID=8YFLogxK
U2 - 10.1128/iai.66.4.1755-1758.1998
DO - 10.1128/iai.66.4.1755-1758.1998
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C2 - 9529109
AN - SCOPUS:0032036390
SN - 0019-9567
VL - 66
SP - 1755
EP - 1758
JO - Infection and Immunity
JF - Infection and Immunity
IS - 4
ER -