Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production

Chaya Kalcheim, Dan Duksin, Zvi Vogel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Coculturing of rat embryonic muscle cells with spinal cord explants resulted in the formation of large numbers of acetylcholine receptor aggregates on the myotube surface, compared to those found on muscle cells grown in the absence of nervous tissue. Remarkably fewer receptor aggregates were formed when, upon addition of nerve explants, these cocultures were treated with either cis-hydroxyproline (a specific inhibitor of collagen production) or collagenase. The possibility is raised that collagen participates in the aggregation of acetylcholine receptors and in synapse formation.

Original languageAmerican English
Pages (from-to)265-270
Number of pages6
JournalNeuroscience Letters
Volume31
Issue number3
DOIs
StatePublished - 31 Aug 1982

Bibliographical note

Funding Information:
This work was supported by the U.S,-Israel Binational Foundation (Z V.) a~d the Israel Cancer Foundation (D,D,),

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