Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production

Chaya Kalcheim; Dan Duksin; Zvi Vogel

doi:10.1016/0304-3940(82)90031-3

Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production

Chaya Kalcheim
, Dan Duksin
, Zvi Vogel

Department of Medical Neurobiology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Coculturing of rat embryonic muscle cells with spinal cord explants resulted in the formation of large numbers of acetylcholine receptor aggregates on the myotube surface, compared to those found on muscle cells grown in the absence of nervous tissue. Remarkably fewer receptor aggregates were formed when, upon addition of nerve explants, these cocultures were treated with either cis-hydroxyproline (a specific inhibitor of collagen production) or collagenase. The possibility is raised that collagen participates in the aggregation of acetylcholine receptors and in synapse formation.

Original language	English
Pages (from-to)	265-270
Number of pages	6
Journal	Neuroscience Letters
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(82)90031-3
State	Published - 31 Aug 1982

Bibliographical note

Funding Information:
This work was supported by the U.S,-Israel Binational Foundation (Z V.) a~d the Israel Cancer Foundation (D,D,),

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10.1016/0304-3940(82)90031-3

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title = "Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production",

abstract = "Coculturing of rat embryonic muscle cells with spinal cord explants resulted in the formation of large numbers of acetylcholine receptor aggregates on the myotube surface, compared to those found on muscle cells grown in the absence of nervous tissue. Remarkably fewer receptor aggregates were formed when, upon addition of nerve explants, these cocultures were treated with either cis-hydroxyproline (a specific inhibitor of collagen production) or collagenase. The possibility is raised that collagen participates in the aggregation of acetylcholine receptors and in synapse formation.",

author = "Chaya Kalcheim and Dan Duksin and Zvi Vogel",

note = "Funding Information: This work was supported by the U.S,-Israel Binational Foundation (Z V.) a\textasciitilde{}d the Israel Cancer Foundation (D,D,),",

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doi = "10.1016/0304-3940(82)90031-3",

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T1 - Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production

AU - Kalcheim, Chaya

AU - Duksin, Dan

AU - Vogel, Zvi

N1 - Funding Information: This work was supported by the U.S,-Israel Binational Foundation (Z V.) a~d the Israel Cancer Foundation (D,D,),

PY - 1982/8/31

Y1 - 1982/8/31

N2 - Coculturing of rat embryonic muscle cells with spinal cord explants resulted in the formation of large numbers of acetylcholine receptor aggregates on the myotube surface, compared to those found on muscle cells grown in the absence of nervous tissue. Remarkably fewer receptor aggregates were formed when, upon addition of nerve explants, these cocultures were treated with either cis-hydroxyproline (a specific inhibitor of collagen production) or collagenase. The possibility is raised that collagen participates in the aggregation of acetylcholine receptors and in synapse formation.

AB - Coculturing of rat embryonic muscle cells with spinal cord explants resulted in the formation of large numbers of acetylcholine receptor aggregates on the myotube surface, compared to those found on muscle cells grown in the absence of nervous tissue. Remarkably fewer receptor aggregates were formed when, upon addition of nerve explants, these cocultures were treated with either cis-hydroxyproline (a specific inhibitor of collagen production) or collagenase. The possibility is raised that collagen participates in the aggregation of acetylcholine receptors and in synapse formation.

UR - https://www.scopus.com/pages/publications/0019911682

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EP - 270

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Aggregation of acetylcholine receptors in nerve-muscle cocultures is decreased by inhibitors of collagen production

Abstract

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