Allelic exclusion in B and T lymphopoiesis

Yehudit Bergman

doi:10.1006/smim.1999.0188

Allelic exclusion in B and T lymphopoiesis

Yehudit Bergman^*

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin structure, and induce V(D)J recombination on one allele preferentially.

Original language	English
Pages (from-to)	319-328
Number of pages	10
Journal	Seminars in Immunology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1006/smim.1999.0188
State	Published - Oct 1999

Bibliographical note

Funding Information:
I thank Raul Mostoslavsky for his help throughout the preparation of this review, and P. Engler and Y. Xu for providing information prior to publication. This research was supported by grants from the Israel Science Foundation, the German—Israeli Foundation for Scientific Research and Development (GIF), and Israel Cancer Association.

Keywords

B cells
Immunoglobulin
Methylation
T cell receptor
V(D)J rearrangement

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10.1006/smim.1999.0188

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abstract = "The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin structure, and induce V(D)J recombination on one allele preferentially.",

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KW - Methylation

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Allelic exclusion in B and T lymphopoiesis

Abstract

Bibliographical note

Keywords

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