Allelic exclusion in B and T lymphopoiesis

Yehudit Bergman

doi:10.1006/smim.1999.0188

Allelic exclusion in B and T lymphopoiesis

Yehudit Bergman^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin structure, and induce V(D)J recombination on one allele preferentially.

Original language	English
Pages (from-to)	319-328
Number of pages	10
Journal	Seminars in Immunology
Volume	11
Issue number	5
DOIs	https://doi.org/10.1006/smim.1999.0188
State	Published - Oct 1999

Keywords

B cells
Immunoglobulin
Methylation
T cell receptor
V(D)J rearrangement

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10.1006/smim.1999.0188

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KW - B cells

KW - Immunoglobulin

KW - Methylation

KW - T cell receptor

KW - V(D)J rearrangement

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Allelic exclusion in B and T lymphopoiesis

Abstract

Keywords

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