TY - JOUR
T1 - AllergoOncology
T2 - Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper
AU - Untersmayr, Eva
AU - Bax, Heather J.
AU - Bergmann, Christoph
AU - Bianchini, Rodolfo
AU - Cozen, Wendy
AU - Gould, Hannah J.
AU - Hartmann, Karin
AU - Josephs, Debra H.
AU - Levi-Schaffer, Francesca
AU - Penichet, Manuel L.
AU - O'Mahony, Liam
AU - Poli, Aurelie
AU - Redegeld, Frank A.
AU - Roth-Walter, Franziska
AU - Turner, Michelle C.
AU - Vangelista, Luca
AU - Karagiannis, Sophia N.
AU - Jensen-Jarolim, Erika
N1 - Publisher Copyright:
© 2019 The Authors. Allergy Published by John Wiley & Sons Ltd.
PY - 2019/6
Y1 - 2019/6
N2 - The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
AB - The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.
KW - allergy
KW - cancer
KW - hygiene hypothesis
KW - microbiota
KW - oncoimmunology
UR - http://www.scopus.com/inward/record.url?scp=85062791620&partnerID=8YFLogxK
U2 - 10.1111/all.13718
DO - 10.1111/all.13718
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C2 - 30636005
AN - SCOPUS:85062791620
SN - 0105-4538
VL - 74
SP - 1037
EP - 1051
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 6
ER -