AllergoOncology – the impact of allergy in oncology: EAACI position paper

E. Jensen-Jarolim; H. J. Bax; R. Bianchini; M. Capron; C. Corrigan; M. Castells; D. Dombrowicz; T. R. Daniels-Wells; J. Fazekas; E. Fiebiger; S. Gatault; H. J. Gould; J. Janda; D. H. Josephs; P. Karagiannis; F. Levi-Schaffer; A. Meshcheryakova; D. Mechtcheriakova; Y. Mekori; F. Mungenast; E. A. Nigro; M. L. Penichet; F. Redegeld; L. Saul; J. Singer; J. F. Spicer; A. G. Siccardi; E. Spillner; M. C. Turner; E. Untersmayr; L. Vangelista; S. N. Karagiannis

doi:10.1111/all.13119

AllergoOncology – the impact of allergy in oncology: EAACI position paper

E. Jensen-Jarolim^*, H. J. Bax, R. Bianchini, M. Capron, C. Corrigan, M. Castells, D. Dombrowicz, T. R. Daniels-Wells, J. Fazekas, E. Fiebiger, S. Gatault, H. J. Gould, J. Janda, D. H. Josephs, P. Karagiannis, F. Levi-Schaffer, A. Meshcheryakova, D. Mechtcheriakova, Y. Mekori, F. MungenastE. A. Nigro, M. L. Penichet, F. Redegeld, L. Saul, J. Singer, J. F. Spicer, A. G. Siccardi, E. Spillner, M. C. Turner, E. Untersmayr, L. Vangelista, S. N. Karagiannis

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

Original language	American English
Pages (from-to)	866-887
Number of pages	22
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	72
Issue number	6
DOIs	https://doi.org/10.1111/all.13119
State	Published - Jun 2017

Bibliographical note

Funding Information:
The AllergoOncology Task Force was financed by the European Academy for Allergy and Clinical Immunology (EAACI). The authors would like to thank EAACI for their financial support in the development of this Task Force report. The authors acknowledge support by the Austrian Science Fund FWF grants P23398-B11, F4606-B28, W1205-B09, (EJJ), KLI284 (EU), P23228-B19 and P22441-B13 (DM); Israel Cancer Association #20161131 and Israel Science Foundation #472/15) (FLS); Cancer Research UK (C30122/A11527; C30122/A15774); The Academy of Medical Sciences (DHJ, SNK, JFS); the Medical Research Council (MR/L023091/1); Breast Cancer Now – the UK's largest breast cancer charity – created by the merger of Breast Cancer Campaign and Breakthrough Breast Cancer (147) (SNK); CR UK/NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587); and NIH/NCI grants R01CA181115 (MLP) and R21CA179680 (TRD). MCT was funded by a Canadian Institutes of Health Research Fellowship. The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas’ NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

Publisher Copyright:
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords

AllergoOncology
IgE
IgG4
allergy
atopy
biologics, desensitization
cancer
chemotherapeutic
clinical oncology
inflammation
tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/all.13119

Cite this

Jensen-Jarolim, E., Bax, H. J., Bianchini, R., Capron, M., Corrigan, C., Castells, M., Dombrowicz, D., Daniels-Wells, T. R., Fazekas, J., Fiebiger, E., Gatault, S., Gould, H. J., Janda, J., Josephs, D. H., Karagiannis, P., Levi-Schaffer, F., Meshcheryakova, A., Mechtcheriakova, D., Mekori, Y., ... Karagiannis, S. N. (2017). AllergoOncology – the impact of allergy in oncology: EAACI position paper. Allergy: European Journal of Allergy and Clinical Immunology, 72(6), 866-887. https://doi.org/10.1111/all.13119

@article{15f6c28a049c4e5493117613c0560a91,

title = "AllergoOncology – the impact of allergy in oncology: EAACI position paper",

abstract = "Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.",

keywords = "AllergoOncology, IgE, IgG4, allergy, atopy, biologics, desensitization, cancer, chemotherapeutic, clinical oncology, inflammation, tumor",

author = "E. Jensen-Jarolim and Bax, {H. J.} and R. Bianchini and M. Capron and C. Corrigan and M. Castells and D. Dombrowicz and Daniels-Wells, {T. R.} and J. Fazekas and E. Fiebiger and S. Gatault and Gould, {H. J.} and J. Janda and Josephs, {D. H.} and P. Karagiannis and F. Levi-Schaffer and A. Meshcheryakova and D. Mechtcheriakova and Y. Mekori and F. Mungenast and Nigro, {E. A.} and Penichet, {M. L.} and F. Redegeld and L. Saul and J. Singer and Spicer, {J. F.} and Siccardi, {A. G.} and E. Spillner and Turner, {M. C.} and E. Untersmayr and L. Vangelista and Karagiannis, {S. N.}",

note = "Funding Information: The AllergoOncology Task Force was financed by the European Academy for Allergy and Clinical Immunology (EAACI). The authors would like to thank EAACI for their financial support in the development of this Task Force report. The authors acknowledge support by the Austrian Science Fund FWF grants P23398-B11, F4606-B28, W1205-B09, (EJJ), KLI284 (EU), P23228-B19 and P22441-B13 (DM); Israel Cancer Association #20161131 and Israel Science Foundation #472/15) (FLS); Cancer Research UK (C30122/A11527; C30122/A15774); The Academy of Medical Sciences (DHJ, SNK, JFS); the Medical Research Council (MR/L023091/1); Breast Cancer Now – the UK's largest breast cancer charity – created by the merger of Breast Cancer Campaign and Breakthrough Breast Cancer (147) (SNK); CR UK/NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587); and NIH/NCI grants R01CA181115 (MLP) and R21CA179680 (TRD). MCT was funded by a Canadian Institutes of Health Research Fellowship. The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas{\textquoteright} NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: {\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2017",

month = jun,

doi = "10.1111/all.13119",

language = "American English",

volume = "72",

pages = "866--887",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

Jensen-Jarolim, E, Bax, HJ, Bianchini, R, Capron, M, Corrigan, C, Castells, M, Dombrowicz, D, Daniels-Wells, TR, Fazekas, J, Fiebiger, E, Gatault, S, Gould, HJ, Janda, J, Josephs, DH, Karagiannis, P, Levi-Schaffer, F, Meshcheryakova, A, Mechtcheriakova, D, Mekori, Y, Mungenast, F, Nigro, EA, Penichet, ML, Redegeld, F, Saul, L, Singer, J, Spicer, JF, Siccardi, AG, Spillner, E, Turner, MC, Untersmayr, E, Vangelista, L & Karagiannis, SN 2017, 'AllergoOncology – the impact of allergy in oncology: EAACI position paper', Allergy: European Journal of Allergy and Clinical Immunology, vol. 72, no. 6, pp. 866-887. https://doi.org/10.1111/all.13119

TY - JOUR

T1 - AllergoOncology – the impact of allergy in oncology

T2 - EAACI position paper

AU - Jensen-Jarolim, E.

AU - Bax, H. J.

AU - Bianchini, R.

AU - Capron, M.

AU - Corrigan, C.

AU - Castells, M.

AU - Dombrowicz, D.

AU - Daniels-Wells, T. R.

AU - Fazekas, J.

AU - Fiebiger, E.

AU - Gatault, S.

AU - Gould, H. J.

AU - Janda, J.

AU - Josephs, D. H.

AU - Karagiannis, P.

AU - Levi-Schaffer, F.

AU - Meshcheryakova, A.

AU - Mechtcheriakova, D.

AU - Mekori, Y.

AU - Mungenast, F.

AU - Nigro, E. A.

AU - Penichet, M. L.

AU - Redegeld, F.

AU - Saul, L.

AU - Singer, J.

AU - Spicer, J. F.

AU - Siccardi, A. G.

AU - Spillner, E.

AU - Turner, M. C.

AU - Untersmayr, E.

AU - Vangelista, L.

AU - Karagiannis, S. N.

N1 - Funding Information: The AllergoOncology Task Force was financed by the European Academy for Allergy and Clinical Immunology (EAACI). The authors would like to thank EAACI for their financial support in the development of this Task Force report. The authors acknowledge support by the Austrian Science Fund FWF grants P23398-B11, F4606-B28, W1205-B09, (EJJ), KLI284 (EU), P23228-B19 and P22441-B13 (DM); Israel Cancer Association #20161131 and Israel Science Foundation #472/15) (FLS); Cancer Research UK (C30122/A11527; C30122/A15774); The Academy of Medical Sciences (DHJ, SNK, JFS); the Medical Research Council (MR/L023091/1); Breast Cancer Now – the UK's largest breast cancer charity – created by the merger of Breast Cancer Campaign and Breakthrough Breast Cancer (147) (SNK); CR UK/NIHR in England/DoH for Scotland, Wales and Northern Ireland Experimental Cancer Medicine Centre (C10355/A15587); and NIH/NCI grants R01CA181115 (MLP) and R21CA179680 (TRD). MCT was funded by a Canadian Institutes of Health Research Fellowship. The research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas’ NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2017/6

Y1 - 2017/6

N2 - Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

AB - Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

KW - AllergoOncology

KW - IgE

KW - IgG4

KW - allergy

KW - atopy

KW - biologics, desensitization

KW - cancer

KW - chemotherapeutic

KW - clinical oncology

KW - inflammation

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=85010387157&partnerID=8YFLogxK

U2 - 10.1111/all.13119

DO - 10.1111/all.13119

M3 - Article

C2 - 28032353

AN - SCOPUS:85010387157

SN - 0105-4538

VL - 72

SP - 866

EP - 887

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 6

ER -

AllergoOncology – the impact of allergy in oncology: EAACI position paper

Abstract

Bibliographical note

Keywords

UN SDGs

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