Alterations in membrane permeability of malaria-infected human erythrocytes are related to the growth stage of the parasite

S. Kutner; D. Baruch; H. Ginsburg; Z. I. Cabantchik

doi:10.1016/0005-2736(82)90178-X

Alterations in membrane permeability of malaria-infected human erythrocytes are related to the growth stage of the parasite

S. Kutner, D. Baruch, H. Ginsburg, Z. I. Cabantchik^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

During the intraerythrocytic growth of Plasmodium falciparum in culture, marked changes are observed in the permeability properties of the host cell membrane. Anionic substances otherwise impermeant to normal cells, become highly permeant to infected cells. These changes in permeability become apparent as rings mature into trophozoites and remain throughout schizogony. The permeability changes to anionic substances are not manifested as degradation of band 3, the purported erythrocyte anion transporter. They probably reflect alterations of a more general nature.

Original language	English
Pages (from-to)	113-117
Number of pages	5
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	687
Issue number	1
DOIs	https://doi.org/10.1016/0005-2736(82)90178-X
State	Published - 23 Apr 1982

Keywords

(Human erythrocyte)
Growth stage
Malaria infection
Membrane permeability

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0005-2736(82)90178-X

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abstract = "During the intraerythrocytic growth of Plasmodium falciparum in culture, marked changes are observed in the permeability properties of the host cell membrane. Anionic substances otherwise impermeant to normal cells, become highly permeant to infected cells. These changes in permeability become apparent as rings mature into trophozoites and remain throughout schizogony. The permeability changes to anionic substances are not manifested as degradation of band 3, the purported erythrocyte anion transporter. They probably reflect alterations of a more general nature.",

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AU - Cabantchik, Z. I.

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N2 - During the intraerythrocytic growth of Plasmodium falciparum in culture, marked changes are observed in the permeability properties of the host cell membrane. Anionic substances otherwise impermeant to normal cells, become highly permeant to infected cells. These changes in permeability become apparent as rings mature into trophozoites and remain throughout schizogony. The permeability changes to anionic substances are not manifested as degradation of band 3, the purported erythrocyte anion transporter. They probably reflect alterations of a more general nature.

AB - During the intraerythrocytic growth of Plasmodium falciparum in culture, marked changes are observed in the permeability properties of the host cell membrane. Anionic substances otherwise impermeant to normal cells, become highly permeant to infected cells. These changes in permeability become apparent as rings mature into trophozoites and remain throughout schizogony. The permeability changes to anionic substances are not manifested as degradation of band 3, the purported erythrocyte anion transporter. They probably reflect alterations of a more general nature.

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Alterations in membrane permeability of malaria-infected human erythrocytes are related to the growth stage of the parasite

Abstract

Keywords

UN SDGs

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