ALTERED TRANSCRIPTION OF AN ONCOGENE IN CHRONIC MYELOID LEUKAEMIA

E. Canaani; D. Steiner-Saltz; E. Aghai; R. P. Gale; A. Berrebi; E. Januszewicz

doi:10.1016/S0140-6736(84)90997-8

ALTERED TRANSCRIPTION OF AN ONCOGENE IN CHRONIC MYELOID LEUKAEMIA

E. Canaani^*, D. Steiner-Saltz, E. Aghai, R. P. Gale, A. Berrebi, E. Januszewicz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Abstract

The oncogene abl, which resides on chromosome 9, is translocated to chromosome 22 as part of the Philadelphia (Ph¹) chromosome. Leukaemic cells from 5 of 6 patients with chronic myelogenous leukaemia (CML) and the Ph¹ chromosome were found to contain a new 8 kb abl RNA transcript. This finding raises the possibility that the abl oncogene is directly involved in the development of CML. It is suggested that the abl gene's expression is altered by the DNA rearrangement in the translocation.

Original language	English
Pages (from-to)	593-595
Number of pages	3
Journal	The Lancet
Volume	323
Issue number	8377
DOIs	https://doi.org/10.1016/S0140-6736(84)90997-8
State	Published - 17 Mar 1984
Externally published	Yes

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10.1016/S0140-6736(84)90997-8

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title = "ALTERED TRANSCRIPTION OF AN ONCOGENE IN CHRONIC MYELOID LEUKAEMIA",

abstract = "The oncogene abl, which resides on chromosome 9, is translocated to chromosome 22 as part of the Philadelphia (Ph1) chromosome. Leukaemic cells from 5 of 6 patients with chronic myelogenous leukaemia (CML) and the Ph1 chromosome were found to contain a new 8 kb abl RNA transcript. This finding raises the possibility that the abl oncogene is directly involved in the development of CML. It is suggested that the abl gene's expression is altered by the DNA rearrangement in the translocation.",

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AU - Steiner-Saltz, D.

AU - Aghai, E.

AU - Gale, R. P.

AU - Berrebi, A.

AU - Januszewicz, E.

PY - 1984/3/17

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N2 - The oncogene abl, which resides on chromosome 9, is translocated to chromosome 22 as part of the Philadelphia (Ph1) chromosome. Leukaemic cells from 5 of 6 patients with chronic myelogenous leukaemia (CML) and the Ph1 chromosome were found to contain a new 8 kb abl RNA transcript. This finding raises the possibility that the abl oncogene is directly involved in the development of CML. It is suggested that the abl gene's expression is altered by the DNA rearrangement in the translocation.

AB - The oncogene abl, which resides on chromosome 9, is translocated to chromosome 22 as part of the Philadelphia (Ph1) chromosome. Leukaemic cells from 5 of 6 patients with chronic myelogenous leukaemia (CML) and the Ph1 chromosome were found to contain a new 8 kb abl RNA transcript. This finding raises the possibility that the abl oncogene is directly involved in the development of CML. It is suggested that the abl gene's expression is altered by the DNA rearrangement in the translocation.

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IS - 8377

ER -

ALTERED TRANSCRIPTION OF AN ONCOGENE IN CHRONIC MYELOID LEUKAEMIA

Abstract

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