Alternative antimicrobial approach: Nano-antimicrobial materials

Nurit Beyth*, Yael Houri-Haddad, Avi Domb, Wahid Khan, Ronen Hazan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

652 Scopus citations

Abstract

Despite numerous existing potent antibiotics and other antimicrobial means, bacterial infections are still a major cause of morbidity and mortality. Moreover, the need to develop additional bactericidal means has significantly increased due to the growing concern regarding multidrug-resistant bacterial strains and biofilm associated infections. Consequently, attention has been especially devoted to new and emerging nanoparticle-based materials in the field of antimicrobial chemotherapy. The present review discusses the activities of nanoparticles as an antimicrobial means, their mode of action, nanoparticle effect on drug-resistant bacteria, and the risks attendant on their use as antibacterial agents. Factors contributing to nanoparticle performance in the clinical setting, their unique properties, and mechanism of action as antibacterial agents are discussed in detail.

Original languageAmerican English
Article number246012
JournalEvidence-based Complementary and Alternative Medicine
Volume2015
DOIs
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© 2015 Nurit Beyth et al.

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