Alzheimer's disease: Isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes

Richard P. Ebstein; Gerald Oppenheim; Jochanan Stessman

doi:10.1016/0024-3205(84)90211-X

Alzheimer's disease: Isoproterenol and prostaglandin E₁-stimulated cyclic AMP accumulation in lymphocytes

Richard P. Ebstein^*
, Gerald Oppenheim
, Jochanan Stessman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Reduced lymphocyte beta-adrenergic receptor activity was observed in patients with Alzheimer's disease and in aged controls; a parallel decline in lymphocytic prostaglandin E₁ receptor activity was seen in the aged controls. In the Alzheimer patients, However, such lymphocytic prostaglandin E₁ receptor activity was significantly raised and correlated with a rating scale for severity of dementia.

Original language	English
Pages (from-to)	2239-2243
Number of pages	5
Journal	Life Sciences
Volume	34
Issue number	23
DOIs	https://doi.org/10.1016/0024-3205(84)90211-X
State	Published - 4 Jun 1984
Externally published	Yes

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10.1016/0024-3205(84)90211-X

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title = "Alzheimer's disease: Isoproterenol and prostaglandin E1-stimulated cyclic AMP accumulation in lymphocytes",

abstract = "Reduced lymphocyte beta-adrenergic receptor activity was observed in patients with Alzheimer's disease and in aged controls; a parallel decline in lymphocytic prostaglandin E1 receptor activity was seen in the aged controls. In the Alzheimer patients, However, such lymphocytic prostaglandin E1 receptor activity was significantly raised and correlated with a rating scale for severity of dementia.",

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AU - Ebstein, Richard P.

AU - Oppenheim, Gerald

AU - Stessman, Jochanan

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Y1 - 1984/6/4

N2 - Reduced lymphocyte beta-adrenergic receptor activity was observed in patients with Alzheimer's disease and in aged controls; a parallel decline in lymphocytic prostaglandin E1 receptor activity was seen in the aged controls. In the Alzheimer patients, However, such lymphocytic prostaglandin E1 receptor activity was significantly raised and correlated with a rating scale for severity of dementia.

AB - Reduced lymphocyte beta-adrenergic receptor activity was observed in patients with Alzheimer's disease and in aged controls; a parallel decline in lymphocytic prostaglandin E1 receptor activity was seen in the aged controls. In the Alzheimer patients, However, such lymphocytic prostaglandin E1 receptor activity was significantly raised and correlated with a rating scale for severity of dementia.

UR - https://www.scopus.com/pages/publications/0021340219

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ER -

Alzheimer's disease: Isoproterenol and prostaglandin E₁-stimulated cyclic AMP accumulation in lymphocytes

Abstract

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