Abstract
Various amide derivatives of o- and p-trimethylsilvlbenzoic acid, p-trimethylsilylphenylacetic acid, and p-trimethylsilylhydrocinnamic acid were prepared starting from the corresponding acids. Preliminary pharmacological evaluation of seven compounds showed that they had some activity as central nervous system depressants; p-trimethylsilylphenylacetylurea was more active than its analog without silicon.
| Original language | English |
|---|---|
| Pages (from-to) | 451-453 |
| Number of pages | 3 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 Mar 1968 |