TY - JOUR
T1 - AMPA receptor neurotransmission and therapeutic applications
T2 - A comprehensive review of their multifaceted modulation
AU - Qneibi, Mohammad
AU - Bdir, Sosana
AU - Bdair, Mohammad
AU - Aldwaik, Samia Ammar
AU - Sandouka, Dana
AU - Heeh, Maram
AU - Idais, Tala Iyad
N1 - Publisher Copyright:
© 2024 Elsevier Masson SAS
PY - 2024/2/15
Y1 - 2024/2/15
N2 - The neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications. This study thoroughly examines the recent developments in AMPA receptor regulation, focusing on a shift from single chemical illustrations to a more extensive investigation of underlying processes. The complex interplay of these modulators in modifying the function and structure of AMPA receptors is the main focus, providing insight into their influence on the speed of excitatory neurotransmission. This research emphasizes the potential of AMPA receptor modulation as a therapy for various neurological disorders such as epilepsy and Alzheimer's disease. Analyzing these regulators' sophisticated molecular details enhances our comprehension of neuropharmacology, representing a significant advancement in using AMPA receptors for treating intricate neurological conditions.
AB - The neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications. This study thoroughly examines the recent developments in AMPA receptor regulation, focusing on a shift from single chemical illustrations to a more extensive investigation of underlying processes. The complex interplay of these modulators in modifying the function and structure of AMPA receptors is the main focus, providing insight into their influence on the speed of excitatory neurotransmission. This research emphasizes the potential of AMPA receptor modulation as a therapy for various neurological disorders such as epilepsy and Alzheimer's disease. Analyzing these regulators' sophisticated molecular details enhances our comprehension of neuropharmacology, representing a significant advancement in using AMPA receptors for treating intricate neurological conditions.
KW - AMPA receptor
KW - Alzheimer's disease
KW - Epilepsy
KW - Negative allosteric modulators
KW - Positive allosteric modulators
UR - http://www.scopus.com/inward/record.url?scp=85183545799&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2024.116151
DO - 10.1016/j.ejmech.2024.116151
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C2 - 38237342
AN - SCOPUS:85183545799
SN - 0223-5234
VL - 266
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
M1 - 116151
ER -