Amplified detection of DNA through an autocatalytic and catabolic DNAzyme-mediated process

Fuan Wang; Johann Elbaz; Carsten Teller; Itamar Willner

doi:10.1002/anie.201005246

Amplified detection of DNA through an autocatalytic and catabolic DNAzyme-mediated process

Fuan Wang
, Johann Elbaz
, Carsten Teller
, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

184 Scopus citations

Abstract

Sense and sensibility: Amplified DNA detection is accomplished by the autocatalytic cleavage of a programmed nucleic acid structure based on the Mg²⁺-dependent DNAzyme E6 (see picture). The analyte sequence is autocatalytically generated by the DNAzyme from a reporter nucleic acid, which is labeled with a fluorophore and quencher at its two ends.

Original language	English
Pages (from-to)	295-299
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	1
DOIs	https://doi.org/10.1002/anie.201005246
State	Published - 3 Jan 2011

Keywords

DNA
DNAzymes
autocatalysis
fluorescence
sensors

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10.1002/anie.201005246

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abstract = "Sense and sensibility: Amplified DNA detection is accomplished by the autocatalytic cleavage of a programmed nucleic acid structure based on the Mg2+-dependent DNAzyme E6 (see picture). The analyte sequence is autocatalytically generated by the DNAzyme from a reporter nucleic acid, which is labeled with a fluorophore and quencher at its two ends.",

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KW - DNAzymes

KW - autocatalysis

KW - fluorescence

KW - sensors

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Amplified detection of DNA through an autocatalytic and catabolic DNAzyme-mediated process

Abstract

Keywords

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