Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator

Fernando Patolsky; Eugenii Katz; Itamar Willner

doi:10.1002/1521-3773(20020916)41:18<3398::AID-ANIE3398>3.0.CO;2-W

Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator

Fernando Patolsky, Eugenii Katz, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

Making light work for DNA detection: Amplified DNA detection is accomplished by doxorubicin intercalated into double-stranded DNA assembled on Au-electrodes. Stimulated electrogenerated biochemiluminescence or biocatalyzed precipitation of an insoluble product amplify the DNA sensing that is being transduced by light emission (see picture; HRP = horseradish peroxidase) or Faradaic impedance spectroscopy, respectively.

Original language	English
Pages (from-to)	3398-3402
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	18
DOIs	https://doi.org/10.1002/1521-3773(20020916)41:18<3398::AID-ANIE3398>3.0.CO;2-W
State	Published - 16 Sep 2002

Keywords

Biosensors
DNA
DNA recognition
Electroluminescence
Impedance spectroscopy
Intercalations

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10.1002/1521-3773(20020916)41:18<3398::AID-ANIE3398>3.0.CO;2-W

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Patolsky, F., Katz, E., & Willner, I. (2002). Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator. Angewandte Chemie - International Edition, 41(18), 3398-3402. https://doi.org/10.1002/1521-3773(20020916)41:18<3398::AID-ANIE3398>3.0.CO;2-W

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abstract = "Making light work for DNA detection: Amplified DNA detection is accomplished by doxorubicin intercalated into double-stranded DNA assembled on Au-electrodes. Stimulated electrogenerated biochemiluminescence or biocatalyzed precipitation of an insoluble product amplify the DNA sensing that is being transduced by light emission (see picture; HRP = horseradish peroxidase) or Faradaic impedance spectroscopy, respectively.",

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Patolsky, F, Katz, E & Willner, I 2002, 'Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator', Angewandte Chemie - International Edition, vol. 41, no. 18, pp. 3398-3402. https://doi.org/10.1002/1521-3773(20020916)41:18<3398::AID-ANIE3398>3.0.CO;2-W

Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator. / Patolsky, Fernando; Katz, Eugenii; Willner, Itamar.
In: Angewandte Chemie - International Edition, Vol. 41, No. 18, 16.09.2002, p. 3398-3402.

Research output: Contribution to journal › Article › peer-review

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Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of the doxorubicin intercalator

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