An application of the Zucker-Wittes modified ratio estimate statistic in the post coronary artery bypass graft (CABG) clinical trial

Paul L. Canner; Bruce Thompson; Genell L. Knatterud; Nancy Geller; Lucien Campeau; David Zucker

doi:10.1016/S0197-2456(96)00232-2

An application of the Zucker-Wittes modified ratio estimate statistic in the post coronary artery bypass graft (CABG) clinical trial

Paul L. Canner^*, Bruce Thompson, Genell L. Knatterud, Nancy Geller, Lucien Campeau, David Zucker

^*Corresponding author for this work

Department of Statistics

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In the Post Coronary Artery Bypass Graft (POST CABG) clinical trial, the primary outcome is substantial worsening (i.e., narrowing of the lumen diameter) of the vein grafts upon comparison of the baseline and follow-up angiograms. The patients had one to five non-occluded vein grafts at entry, so there may be from one to five primary outcome responses per patient. A modified ratio estimate (MRE) statistic, as described previously by Zucker and Wittes, may be used to analyze data of this kind. In the present paper we propose a more powerful MRE statistic when the event rates and/ or intraclass correlations vary according to number of grafts per patient. We also adapt this statistic to the factorial treatment design of the POST CABG clinical trial.

Original language	English
Pages (from-to)	318-327
Number of pages	10
Journal	Controlled Clinical Trials
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/S0197-2456(96)00232-2
State	Published - Aug 1997

Bibliographical note

Funding Information:
The authors wish to thank Dr. John M. Neuhaus and the journal referees for their helpful review of this paper. Support for the POST CABG clinical trial came from National Heart, Lung, and Blood Institute Contract No. NOl-HC-75076.

Keywords

Controlled clinical trial
Coronary artery bypass grafts surgery
Ratio estimate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0197-2456(96)00232-2

Cite this

@article{706c61ef83104afca2ee4fe206bb8589,

title = "An application of the Zucker-Wittes modified ratio estimate statistic in the post coronary artery bypass graft (CABG) clinical trial",

abstract = "In the Post Coronary Artery Bypass Graft (POST CABG) clinical trial, the primary outcome is substantial worsening (i.e., narrowing of the lumen diameter) of the vein grafts upon comparison of the baseline and follow-up angiograms. The patients had one to five non-occluded vein grafts at entry, so there may be from one to five primary outcome responses per patient. A modified ratio estimate (MRE) statistic, as described previously by Zucker and Wittes, may be used to analyze data of this kind. In the present paper we propose a more powerful MRE statistic when the event rates and/ or intraclass correlations vary according to number of grafts per patient. We also adapt this statistic to the factorial treatment design of the POST CABG clinical trial.",

keywords = "Controlled clinical trial, Coronary artery bypass grafts surgery, Ratio estimate",

author = "Canner, {Paul L.} and Bruce Thompson and Knatterud, {Genell L.} and Nancy Geller and Lucien Campeau and David Zucker",

note = "Funding Information: The authors wish to thank Dr. John M. Neuhaus and the journal referees for their helpful review of this paper. Support for the POST CABG clinical trial came from National Heart, Lung, and Blood Institute Contract No. NOl-HC-75076.",

year = "1997",

month = aug,

doi = "10.1016/S0197-2456(96)00232-2",

language = "אנגלית",

volume = "18",

pages = "318--327",

journal = "Controlled Clinical Trials",

issn = "0197-2456",

publisher = "Elsevier BV",

number = "4",

}

TY - JOUR

T1 - An application of the Zucker-Wittes modified ratio estimate statistic in the post coronary artery bypass graft (CABG) clinical trial

AU - Canner, Paul L.

AU - Thompson, Bruce

AU - Knatterud, Genell L.

AU - Geller, Nancy

AU - Campeau, Lucien

AU - Zucker, David

N1 - Funding Information: The authors wish to thank Dr. John M. Neuhaus and the journal referees for their helpful review of this paper. Support for the POST CABG clinical trial came from National Heart, Lung, and Blood Institute Contract No. NOl-HC-75076.

PY - 1997/8

Y1 - 1997/8

N2 - In the Post Coronary Artery Bypass Graft (POST CABG) clinical trial, the primary outcome is substantial worsening (i.e., narrowing of the lumen diameter) of the vein grafts upon comparison of the baseline and follow-up angiograms. The patients had one to five non-occluded vein grafts at entry, so there may be from one to five primary outcome responses per patient. A modified ratio estimate (MRE) statistic, as described previously by Zucker and Wittes, may be used to analyze data of this kind. In the present paper we propose a more powerful MRE statistic when the event rates and/ or intraclass correlations vary according to number of grafts per patient. We also adapt this statistic to the factorial treatment design of the POST CABG clinical trial.

AB - In the Post Coronary Artery Bypass Graft (POST CABG) clinical trial, the primary outcome is substantial worsening (i.e., narrowing of the lumen diameter) of the vein grafts upon comparison of the baseline and follow-up angiograms. The patients had one to five non-occluded vein grafts at entry, so there may be from one to five primary outcome responses per patient. A modified ratio estimate (MRE) statistic, as described previously by Zucker and Wittes, may be used to analyze data of this kind. In the present paper we propose a more powerful MRE statistic when the event rates and/ or intraclass correlations vary according to number of grafts per patient. We also adapt this statistic to the factorial treatment design of the POST CABG clinical trial.

KW - Controlled clinical trial

KW - Coronary artery bypass grafts surgery

KW - Ratio estimate

UR - http://www.scopus.com/inward/record.url?scp=0030792174&partnerID=8YFLogxK

U2 - 10.1016/S0197-2456(96)00232-2

DO - 10.1016/S0197-2456(96)00232-2

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 9257071

AN - SCOPUS:0030792174

SN - 0197-2456

VL - 18

SP - 318

EP - 327

JO - Controlled Clinical Trials

JF - Controlled Clinical Trials

IS - 4

ER -

An application of the Zucker-Wittes modified ratio estimate statistic in the post coronary artery bypass graft (CABG) clinical trial

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this