An Au nanoparticle/bisbipyridinium cyclophane-functionalized ion- sensitive field-effect transistor for the sensing of adrenaline

Andrei B. Kharitonov, Andrew N. Shipway, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

A film consisting of polyethyleneimine (PEI), Au nanoparticles (12 ± 1 nm) and coadsorbed cyclobis(paraquat-p-phenylene) (1) was assembled as a sensing interface on the Al23 insulating layer of an ion-sensitive field- effect transistor (ISFET). Adrenaline (2) was sensed by the functionalized ISFET with a detection limit of 1 x 10-6 M. The sensing ability of the nanostructured device for the analysis of adrenaline originates from the preconcentration of the analyte in the cyclophane by π-π donor-acceptor interactions. Analysis of adrenaline is accomplished by the measurement of the source-drain current, I(sd), or by the gate-source voltage, V(gs). The sensing device is reusable (at least 100 cycles) and exhibits high stability.

Original languageEnglish
Pages (from-to)5441-5443
Number of pages3
JournalAnalytical Chemistry
Volume71
Issue number23
DOIs
StatePublished - 1 Dec 1999

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