An Efficient and Waste-Minimized One-Pot Procedure for the Preparation of N-Boc-γ-amino Alcohols Starting from α,β-Unsaturated Ketones in Flow

Eleonora Ballerini, Raimondo Maggi, Ferdinando Pizzo, Oriana Piermatti, Dmitri Gelman*, Luigi Vaccaro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.

Original languageAmerican English
Pages (from-to)474-479
Number of pages6
JournalOrganic Process Research and Development
Volume20
Issue number2
DOIs
StatePublished - 19 Feb 2016

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

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