Abstract
We report herein a clean multistep flow process that starting from α,β-unsaturated ketones 1 allows the preparation of N-Boc-γ-amino alcohols 3 in high yields. The final products have been isolated in pure form without any additional purification step. The cleanness and environmental efficiency achieved using our protocol are proven by the calculation of green metrics such as E-factors.
Original language | English |
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Pages (from-to) | 474-479 |
Number of pages | 6 |
Journal | Organic Process Research and Development |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - 19 Feb 2016 |
Bibliographical note
Publisher Copyright:© 2015 American Chemical Society.