An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats

Yehuda Shavit, Michael Myslobodsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume10
Issue number2
DOIs
StatePublished - Feb 1979
Externally publishedYes

Keywords

  • Dopamine asymmetry
  • Hemispheric asymmetry
  • Rotation behavior
  • Visual evoked potential

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