An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats

Yehuda Shavit; Michael Myslobodsky

doi:10.1016/0091-3057(79)90086-8

An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats

Yehuda Shavit
, Michael Myslobodsky^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.

Original language	English
Pages (from-to)	195-199
Number of pages	5
Journal	Pharmacology Biochemistry and Behavior
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/0091-3057(79)90086-8
State	Published - Feb 1979
Externally published	Yes

Keywords

Dopamine asymmetry
Hemispheric asymmetry
Rotation behavior
Visual evoked potential

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10.1016/0091-3057(79)90086-8

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abstract = "Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.",

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author = "Yehuda Shavit and Michael Myslobodsky",

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AB - Ten out of eleven Wistar rats displayed a reliable interhemispheric asymmetry of the secondary slow negative wave (SNW) of the visual evoked potential. A more synchronized EEG was observed on the side of facilitated SNW. The analysis of rotation directionality in the rotometer of these rats after IP (+)-amphetamine administration (1.25 mg/kg) showed that rats reliably rotated towards the side with a more facilitated SNW. It is believed that an imbalance of nigrostriatal DA content underlies the interhemispheric asymmetry of EEG and evoked potentials.

KW - Dopamine asymmetry

KW - Hemispheric asymmetry

KW - Rotation behavior

KW - Visual evoked potential

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An electrophysiological correlate of amphetamine revealed motor imbalance in albino rats

Abstract

Keywords

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