An empirical extremum principle for the Hill coefficient in ligand-protein interactions showing negative cooperativity

Hagai Abeliovich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

The Hill coefficient (nH) is a central parameter in the study of ligand-protein interactions, which measures the degree of cooperativity between subunits that bind the ligand in multisubunit proteins. The most common usage of nH is as an estimate of the minimal number of interacting binding sites in positively cooperating systems. In the present study, a statistical interpretation of nH for a generalized system of multiple identical binding sites is developed. This interpretation is then applied to the derivation of an empirical extremum principle for nH in negatively cooperating systems of identical binding sites, which can be used for the estimation of the minimal number of interacting sites in such systems.

Original languageAmerican English
Pages (from-to)76-79
Number of pages4
JournalBiophysical Journal
Volume89
Issue number1
DOIs
StatePublished - Jul 2005

Bibliographical note

Funding Information:
H.A. is supported by grant No. 496/03 from the Israel Science Foundation.

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