TY - JOUR
T1 - An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure
AU - Bousquet, Pascal
AU - Feldman, Josiane
AU - Atlas, Daphné
PY - 1986/5/13
Y1 - 1986/5/13
N2 - We report here that topical application of clonidine displacing substance (CDS), an endogenous brain extract, directly in the nucleus reticularis lateralis (NRL) region of anaesthetized cats regularly produced hypertension. CDS (5 units) increased the mean blood pressure by 40 ± 8%. Pretreatment of anaesthetized rabbits with intracisternal CDS (500 units) shifted to the right the dose-response curve obtained with clonidine alone injected the same way. This brain extract might be considered as an endogenous antagonist for the hypotensive effects of clonidine at least in the NRL region.
AB - We report here that topical application of clonidine displacing substance (CDS), an endogenous brain extract, directly in the nucleus reticularis lateralis (NRL) region of anaesthetized cats regularly produced hypertension. CDS (5 units) increased the mean blood pressure by 40 ± 8%. Pretreatment of anaesthetized rabbits with intracisternal CDS (500 units) shifted to the right the dose-response curve obtained with clonidine alone injected the same way. This brain extract might be considered as an endogenous antagonist for the hypotensive effects of clonidine at least in the NRL region.
KW - Clonidine displacing substance Blood pressure Brainstem Clonidine
UR - http://www.scopus.com/inward/record.url?scp=0022459004&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(86)90138-X
DO - 10.1016/0014-2999(86)90138-X
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C2 - 3720837
AN - SCOPUS:0022459004
SN - 0014-2999
VL - 124
SP - 167
EP - 170
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1-2
ER -