@inproceedings{3191d0b33f3d467a86d8c15ba109ae5b,
title = "An expectation-maximization algorithm for analysis of evolution of exon-intron structure of eukaryotic genes",
abstract = "We propose a detailed model of evolution of exon-intron structure of eukaryotic genes that takes into account gene-specific intron gain and loss rates, branch-specific gain and loss coefficients, invariant sites incapable of intron gain, and rate variability of both gain and loss which is gamma-distributed across sites. We develop an expectation-maximization algorithm to estimate the parameters of this model, and study its performance using simulated data.",
author = "Liran Carmel and Rogozin, {Igor B.} and Wolf, {Yuri I.} and Koonin, {Eugene V.}",
year = "2005",
doi = "10.1007/11554714_4",
language = "אנגלית",
isbn = "3540289321",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
pages = "35--46",
booktitle = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
note = "RECOMB 2005 International Workshop on Comparative Genomics, RCG 2005 ; Conference date: 18-09-2005 Through 20-09-2005",
}