An immunochemical approach for the determination of trace amounts of enantiomeric impurities

O. Hofstetter*, H. Hofstetter, M. Wilchek, V. Schurig, B. S. Green

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The application of stereoselective antibodies in an enzyme immunoassay enables the quantitative determination of enantiomeric impurities beyond the outer limits of currently available methods; thus, using an antibody raised against a derivative of D-phenylalanine, the D-enantiomer of the free amino acid can be detected in a 100 000 fold excess of the L-enantiomer (ee 99.998%).

Original languageEnglish
Pages (from-to)1581-1582
Number of pages2
JournalChemical Communications
Issue number17
DOIs
StatePublished - 7 Sep 2000
Externally publishedYes

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