An immunochemical approach for the determination of trace amounts of enantiomeric impurities

O. Hofstetter; H. Hofstetter; M. Wilchek; V. Schurig; B. S. Green

doi:10.1039/b004587j

An immunochemical approach for the determination of trace amounts of enantiomeric impurities

O. Hofstetter^*
, H. Hofstetter
, M. Wilchek
, V. Schurig
, B. S. Green

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The application of stereoselective antibodies in an enzyme immunoassay enables the quantitative determination of enantiomeric impurities beyond the outer limits of currently available methods; thus, using an antibody raised against a derivative of D-phenylalanine, the D-enantiomer of the free amino acid can be detected in a 100 000 fold excess of the L-enantiomer (ee 99.998%).

Original language	English
Pages (from-to)	1581-1582
Number of pages	2
Journal	Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/b004587j
State	Published - 7 Sep 2000
Externally published	Yes

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10.1039/b004587j

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title = "An immunochemical approach for the determination of trace amounts of enantiomeric impurities",

abstract = "The application of stereoselective antibodies in an enzyme immunoassay enables the quantitative determination of enantiomeric impurities beyond the outer limits of currently available methods; thus, using an antibody raised against a derivative of D-phenylalanine, the D-enantiomer of the free amino acid can be detected in a 100 000 fold excess of the L-enantiomer (ee 99.998\%).",

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AU - Hofstetter, O.

AU - Hofstetter, H.

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AU - Schurig, V.

AU - Green, B. S.

PY - 2000/9/7

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N2 - The application of stereoselective antibodies in an enzyme immunoassay enables the quantitative determination of enantiomeric impurities beyond the outer limits of currently available methods; thus, using an antibody raised against a derivative of D-phenylalanine, the D-enantiomer of the free amino acid can be detected in a 100 000 fold excess of the L-enantiomer (ee 99.998%).

AB - The application of stereoselective antibodies in an enzyme immunoassay enables the quantitative determination of enantiomeric impurities beyond the outer limits of currently available methods; thus, using an antibody raised against a derivative of D-phenylalanine, the D-enantiomer of the free amino acid can be detected in a 100 000 fold excess of the L-enantiomer (ee 99.998%).

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JF - Chemical Communications

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An immunochemical approach for the determination of trace amounts of enantiomeric impurities

Abstract

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