TY - JOUR
T1 - An improved method for the catalytic preparation of t-butyl esters of carboxylic and fatty acids
AU - Wiener, Harold
AU - Gilon, Chaim
PY - 1986/9
Y1 - 1986/9
N2 - Esterification of various acids such as fatty acids, simple carboxylic acids, and Nα blocked amino acids by t-butanol in very high yield is described. The one-pot esterification is achieved by dicyclohexylcarbodiimide (DCC) and catalyzed by dimethylaminopyridine (DMAP). This procedure overcomes the excessive formation of the undesired side product, N-acyl urea obtained normally when a DCC/DMAP-mediated esterification of fatty acids is attempted. The procedure is based on studies of reaction rate and product distribution under various reaction conditions. A suggested mechanism for the esterification of fatty acids is presented.
AB - Esterification of various acids such as fatty acids, simple carboxylic acids, and Nα blocked amino acids by t-butanol in very high yield is described. The one-pot esterification is achieved by dicyclohexylcarbodiimide (DCC) and catalyzed by dimethylaminopyridine (DMAP). This procedure overcomes the excessive formation of the undesired side product, N-acyl urea obtained normally when a DCC/DMAP-mediated esterification of fatty acids is attempted. The procedure is based on studies of reaction rate and product distribution under various reaction conditions. A suggested mechanism for the esterification of fatty acids is presented.
UR - http://www.scopus.com/inward/record.url?scp=0001835210&partnerID=8YFLogxK
U2 - 10.1016/0304-5102(86)85136-7
DO - 10.1016/0304-5102(86)85136-7
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AN - SCOPUS:0001835210
SN - 0304-5102
VL - 37
SP - 45
EP - 52
JO - Journal of Molecular Catalysis
JF - Journal of Molecular Catalysis
IS - 1
ER -