TY - JOUR
T1 - An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis
AU - Tashma, Z.
AU - Deutsch, J.
AU - Cohen, S.
AU - Weisz, M.
AU - Katzhendler, J.
AU - Ringel, I.
PY - 1987/6/1
Y1 - 1987/6/1
N2 - The reaction between phosphorus trichloride (PCl3) and trimethyl phosphite (CH3O)3P has been examined by 31Pnmr, in order to achieve a simple and efficient procedure for the formation of methyl dichlorophosphite (CH3OPCl2), which is a key intermediate in the synthesis of oligonucleo-tides. The yield of the reaction was also studied on a preparative scale and it was found that the optimal condition is obtained when the reactants molar ratio is 1:1.
AB - The reaction between phosphorus trichloride (PCl3) and trimethyl phosphite (CH3O)3P has been examined by 31Pnmr, in order to achieve a simple and efficient procedure for the formation of methyl dichlorophosphite (CH3OPCl2), which is a key intermediate in the synthesis of oligonucleo-tides. The yield of the reaction was also studied on a preparative scale and it was found that the optimal condition is obtained when the reactants molar ratio is 1:1.
UR - http://www.scopus.com/inward/record.url?scp=84953486346&partnerID=8YFLogxK
U2 - 10.1080/07328318708069988
DO - 10.1080/07328318708069988
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:84953486346
SN - 0732-8311
VL - 6
SP - 589
EP - 595
JO - Nucleosides and Nucleotides
JF - Nucleosides and Nucleotides
IS - 3
ER -