An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis

Z. Tashma; J. Deutsch; S. Cohen; M. Weisz; J. Katzhendler; I. Ringel

doi:10.1080/07328318708069988

An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis

Z. Tashma
, J. Deutsch
, S. Cohen
, M. Weisz
, J. Katzhendler
, I. Ringel

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

The reaction between phosphorus trichloride (PCl₃) and trimethyl phosphite (CH₃O)₃P has been examined by ³¹Pnmr, in order to achieve a simple and efficient procedure for the formation of methyl dichlorophosphite (CH₃OPCl₂), which is a key intermediate in the synthesis of oligonucleo-tides. The yield of the reaction was also studied on a preparative scale and it was found that the optimal condition is obtained when the reactants molar ratio is 1:1.

Original language	English
Pages (from-to)	589-595
Number of pages	7
Journal	Nucleosides and Nucleotides
Volume	6
Issue number	3
DOIs	https://doi.org/10.1080/07328318708069988
State	Published - 1 Jun 1987

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abstract = "The reaction between phosphorus trichloride (PCl3) and trimethyl phosphite (CH3O)3P has been examined by 31Pnmr, in order to achieve a simple and efficient procedure for the formation of methyl dichlorophosphite (CH3OPCl2), which is a key intermediate in the synthesis of oligonucleo-tides. The yield of the reaction was also studied on a preparative scale and it was found that the optimal condition is obtained when the reactants molar ratio is 1:1.",

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AU - Katzhendler, J.

AU - Ringel, I.

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AB - The reaction between phosphorus trichloride (PCl3) and trimethyl phosphite (CH3O)3P has been examined by 31Pnmr, in order to achieve a simple and efficient procedure for the formation of methyl dichlorophosphite (CH3OPCl2), which is a key intermediate in the synthesis of oligonucleo-tides. The yield of the reaction was also studied on a preparative scale and it was found that the optimal condition is obtained when the reactants molar ratio is 1:1.

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An improved method for the preparation of methyl dichlorophosphite. A key reagent in the phosphite method of oligonucleotide synthesis

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