Abstract
An improved synthetic procedure for the synthesis of 6- and 7-hydroxyindoles is described. In this method, the addition of two chlorine atoms in 1-benzyloxy-4,5-dichloro-2-nitrobenzene (3) and 1-benzyloxy-2,6- dichloro-3-nitrobenzene (9) facilitated the subsequent cyanomethylation step to give substituted cyanomethyl-dichloronitrobenzenes 4 and 10, leading to an overall increase in the yield of the hydroxyindoles 6 and 12.
Original language | English |
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Pages (from-to) | 3043-3046 |
Number of pages | 4 |
Journal | Synthesis |
Issue number | 18 |
DOIs | |
State | Published - 17 Dec 2004 |
Keywords
- Cyanomethylation
- Hydroxyindoles
- Indole synthesis