An improved synthesis of hydroxyindoles

Lena Lerman, Marta Weinstock-Rosin, Abraham Nudelman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

An improved synthetic procedure for the synthesis of 6- and 7-hydroxyindoles is described. In this method, the addition of two chlorine atoms in 1-benzyloxy-4,5-dichloro-2-nitrobenzene (3) and 1-benzyloxy-2,6- dichloro-3-nitrobenzene (9) facilitated the subsequent cyanomethylation step to give substituted cyanomethyl-dichloronitrobenzenes 4 and 10, leading to an overall increase in the yield of the hydroxyindoles 6 and 12.

Original languageEnglish
Pages (from-to)3043-3046
Number of pages4
JournalSynthesis
Issue number18
DOIs
StatePublished - 17 Dec 2004

Keywords

  • Cyanomethylation
  • Hydroxyindoles
  • Indole synthesis

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