An improved synthesis of hydroxyindoles

Lena Lerman; Marta Weinstock-Rosin; Abraham Nudelman

doi:10.1055/s-2004-834924

An improved synthesis of hydroxyindoles

Lena Lerman
, Marta Weinstock-Rosin
, Abraham Nudelman^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

An improved synthetic procedure for the synthesis of 6- and 7-hydroxyindoles is described. In this method, the addition of two chlorine atoms in 1-benzyloxy-4,5-dichloro-2-nitrobenzene (3) and 1-benzyloxy-2,6- dichloro-3-nitrobenzene (9) facilitated the subsequent cyanomethylation step to give substituted cyanomethyl-dichloronitrobenzenes 4 and 10, leading to an overall increase in the yield of the hydroxyindoles 6 and 12.

Original language	English
Pages (from-to)	3043-3046
Number of pages	4
Journal	Synthesis
Issue number	18
DOIs	https://doi.org/10.1055/s-2004-834924
State	Published - 17 Dec 2004

Keywords

Cyanomethylation
Hydroxyindoles
Indole synthesis

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10.1055/s-2004-834924

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title = "An improved synthesis of hydroxyindoles",

abstract = "An improved synthetic procedure for the synthesis of 6- and 7-hydroxyindoles is described. In this method, the addition of two chlorine atoms in 1-benzyloxy-4,5-dichloro-2-nitrobenzene (3) and 1-benzyloxy-2,6- dichloro-3-nitrobenzene (9) facilitated the subsequent cyanomethylation step to give substituted cyanomethyl-dichloronitrobenzenes 4 and 10, leading to an overall increase in the yield of the hydroxyindoles 6 and 12.",

keywords = "Cyanomethylation, Hydroxyindoles, Indole synthesis",

author = "Lena Lerman and Marta Weinstock-Rosin and Abraham Nudelman",

year = "2004",

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doi = "10.1055/s-2004-834924",

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T1 - An improved synthesis of hydroxyindoles

AU - Lerman, Lena

AU - Weinstock-Rosin, Marta

AU - Nudelman, Abraham

PY - 2004/12/17

Y1 - 2004/12/17

N2 - An improved synthetic procedure for the synthesis of 6- and 7-hydroxyindoles is described. In this method, the addition of two chlorine atoms in 1-benzyloxy-4,5-dichloro-2-nitrobenzene (3) and 1-benzyloxy-2,6- dichloro-3-nitrobenzene (9) facilitated the subsequent cyanomethylation step to give substituted cyanomethyl-dichloronitrobenzenes 4 and 10, leading to an overall increase in the yield of the hydroxyindoles 6 and 12.

AB - An improved synthetic procedure for the synthesis of 6- and 7-hydroxyindoles is described. In this method, the addition of two chlorine atoms in 1-benzyloxy-4,5-dichloro-2-nitrobenzene (3) and 1-benzyloxy-2,6- dichloro-3-nitrobenzene (9) facilitated the subsequent cyanomethylation step to give substituted cyanomethyl-dichloronitrobenzenes 4 and 10, leading to an overall increase in the yield of the hydroxyindoles 6 and 12.

KW - Cyanomethylation

KW - Hydroxyindoles

KW - Indole synthesis

UR - https://www.scopus.com/pages/publications/11144260897

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DO - 10.1055/s-2004-834924

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SN - 0039-7881

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EP - 3046

JO - Synthesis

JF - Synthesis

IS - 18

ER -

An improved synthesis of hydroxyindoles

Abstract

Keywords

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