An iodine-calcium separation analysis and virtually non-contrasted image generation obtained with single source dual energy MDCT

Liran Goshen*, Jacob Sosna, Raz Carmi, Galit Kafri, Igal Iancu, Ami Altman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Scopus citations

Abstract

Dual energy CT enables the differentiation between various materials by analyzing their unique attenuation spectral response. These responses are represented as vectors on an image-based energy map. Practically, this spectral information can be very noisy requiring further analysis. Furthermore, the material response vectors may be affected by beam-hardening and varied between images. A new dual-energy analysis, approach is proposed to improve iodine-calcium separation. The new algorithm estimates the material response vectors of iodine, calcium and soft tissue. Then it estimates a voxel probability to be either iodine or calcium. This algorithm yields a better separation between iodine and calcium compounds. The above analysis can be used to generate virtually noncontrasted images. A complementary algorithm uses the estimated probabilities and the material response vectors to replace the iodine Hounsfield unit enhancement by the original soft tissue texture. This algorithm has the potential to eliminate the need for an initial non-contrast scan in multi-phasic MDCT clinical procedures, leading to reduced radiation exposure and fully registered studies. Phantom and clinical studies were performed using a single source double-decker dual-energy MDCT prototype. The results showed a robust and reproducible iodine-calcium separation, even in cases with low dose and beam hardening effects. The virtual images, evaluated by two experienced radiologists, had similar image quality as compared to conventional noncontrasted images.

Original languageAmerican English
Title of host publication2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages3868-3870
Number of pages3
DOIs
StatePublished - 2008
Externally publishedYes
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: 19 Oct 200825 Oct 2008

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Conference

Conference2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Country/TerritoryGermany
CityDresden
Period19/10/0825/10/08

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