An upstream repressor element plays a role in Igf2 imprinting

Sharon Eden, Miguel Constancia, Tamar Hashimshony, Wendy Dean, Beth Goldstein, Alfred C. Johnson, Ilana Keshet, Wolf Reik, Howard Cedar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a transacting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.

Original languageAmerican English
Pages (from-to)3518-3525
Number of pages8
JournalEMBO Journal
Issue number13
StatePublished - 2 Jul 2001


  • GCF
  • Imprinting
  • Methylation


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