Analysis of genetic toggle switch systems encoded on plasmids

Adiel Loinger*, Ofer Biham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Genetic switch systems with mutual repression of two transcription factors, encoded on plasmids, are studied using stochastic methods. The plasmid copy number is found to strongly affect the behavior of these systems. More specifically, the average time between spontaneous switching events quickly increases with the number of plasmids. It was shown before that for a single copy encoded on the chromosome, the exclusive switch is more stable than the general switch. Here we show that when the switch is encoded on a sufficiently large number of plasmids, the situation is reversed and the general switch is more stable than the exclusive switch. These predictions can be tested experimentally using methods of synthetic biology.

Original languageAmerican English
Article number068104
JournalPhysical Review Letters
Issue number6
StatePublished - 7 Aug 2009


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