Analysis of rare amino acid replacements supports the coelomata clade

Igor B. Rogozin*, Yuri I. Wolf, Liran Carmel, Eugene V. Koonin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The recent analysis of a novel class of rare genomic changes, RGC_CAMs (after conserved amino acids - multiple substitutions), supported the Coelomata clade of animals as opposed to the Ecdysozoa clade (Rogozin et al. 2007). A subsequent reanalysis, with the sequences from the sea anemone Nematostella vectensis included in the set of outgroup species, suggested that this result was an artifact caused by reverse amino replacements and claimed support for Ecdysozoa (Irimia et al. 2007). We show that the internal branch connecting the sea anemone to the bilaterian animals is extremely short, resulting in a weak statistical support for the Coelomata clade. Direct estimation of the level of homoplasy, combined with taxon sampling with different sets of outgroup species, reinforces the support for Coelomata, whereas the effect of reversals is shown to be relatively minor.

Original languageAmerican English
Pages (from-to)2594-2597
Number of pages4
JournalMolecular Biology and Evolution
Issue number12
StatePublished - Dec 2007
Externally publishedYes


  • Cladistics
  • Coelomata
  • Ecdysozoa
  • Phylogenetic analysis
  • Rare genomic changes


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