Analysis of the genetic basis of height in large Jewish nuclear families

Danny Zeevi*, Joshua S. Bloom, Meru J. Sadhu, Adi Ben Yehuda, David Zangen, Ephrat Levy-Lahad, Leonid Kruglyak

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Despite intensive study, most of the specific genetic factors that contribute to variation in human height remain undiscovered. We conducted a family-based linkage study of height in a unique cohort of very large nuclear families from a founder (Jewish) population. This design allowed for increased power to detect linkage, compared to previous family-based studies. Loci we identified in discovery families could explain an estimated lower bound of 6% of the variance in height in validation families. We showed that these loci are not tagging known common variants associated with height. Rather, we suggest that the observed signals arise from variants with large effects that are rare globally but elevated in frequency in the Jewish population.

Original languageAmerican English
Article numbere1008082
JournalPLoS Genetics
Issue number7
StatePublished - Jul 2019

Bibliographical note

Funding Information:
Funding was provided by the Howard Hughes Medical Institute (L.K. and D.Ze), the James S. McDonnell Centennial Fellowship in Human Genetics (L.K.), The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Kruglyak laboratory members for helpful discussion, Eran Segal for lab space and equipment, and the Puah Institute for help in the recruitment of participants.

Publisher Copyright:
© 2019 Zeevi et al.


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