Angiogenesis in asthma

D. Ribatti; I. Puxeddu; E. Crivellato; B. Nico; A. Vacca; F. Levi-Schaffer

doi:10.1111/j.1365-2222.2009.03385.x

Angiogenesis in asthma

D. Ribatti^*
, I. Puxeddu
, E. Crivellato
, B. Nico
, A. Vacca
, F. Levi-Schaffer

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Asthma is a chronic inflammatory disease of the airways characterized by infiltration and activation of inflammatory cells and by structural changes, including subepithelial fibrosis, smooth muscle cells hypertrophy/hyperplasia, epithelial cell metaplasia and angiogenesis. These structural changes are thought to correlate with asthma severity and to account for the development of progressive lung function deterioration. The mechanism underlying airway angiogenesis in asthma and its precise clinical relevance have not yet been completely elucidated. This review provides recent data showing the contribution of allergic inflammation in increased airway vascularity and potential therapeutical approaches in asthma treatment by acting on bronchial microvascular changes.

Original language	English
Pages (from-to)	1815-1821
Number of pages	7
Journal	Clinical and Experimental Allergy
Volume	39
Issue number	12
DOIs	https://doi.org/10.1111/j.1365-2222.2009.03385.x
State	Published - Dec 2009

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1111/j.1365-2222.2009.03385.x

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AU - Crivellato, E.

AU - Nico, B.

AU - Vacca, A.

AU - Levi-Schaffer, F.

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Angiogenesis in asthma

Abstract

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